Molly O’Shea

60% of Vercel Deployments Are Now Shipped by AI Agents

Oct 16, 2026 · 1:29:09

Vercel CEO Guillermo Rauch argues AI agents, not humans, are becoming the internet's primary users — and Vercel the infrastructure they choose. Coding agents went from 3% to 60% of Vercel deployments in a year, and the $9.3B-valued company reports $600M annualized revenue and 485,000 paying teams. He says engineers now manage agents like engineering managers, enterprises will generate personalized software instead of buying SaaS while Salesforce survives as data infrastructure, and websites must retool for agents via MCP. Vercel's AI Gateway shows 80% of tokens flow to open models — frontier labs, he argues, face fleeting loyalty and crypto-like froth. He details a $1M sandbox bounty that surfaced a critical Linux vulnerability and predicts fluid compute as serverless's next chapter.

Thrive Capital’s Dr. Nworah Ayogu on Why Neuralink Is More Interesting Than SpaceX

Oct 14, 2026 · 1:10:25

Dr. Nworah Ayogu, physician and Partner at Thrive Capital, argues AI's most important breakthroughs will happen in medicine, pointing to portfolio companies like Isomorphic Labs, Neuralink, OpenEvidence, and Cadence. He explains how Isomorphic Labs could cut drug development from 10 years to 4, and why Neuralink—more interesting than SpaceX, he argues—insources everything from neurosurgical robots to pathology labs. OpenEvidence reached two-thirds of US physicians in three years versus Epic's sub-50% share after 40. He details Cadence cutting hospitalizations 25% and saving Medicare $2.5M weekly, OpenAI's 300 million weekly health questions, and $40 trillion spent over a decade with no life expectancy gains, closing with his case that America needs a 10X nurse more than a 10X engineer.

Perplexity CEO: SMBs Could Drive the Next Economic Boom

Oct 12, 2026 · 54:45

Perplexity CEO Aravind Srinivas tells Molly O'Shea that the next wave of American economic growth will come from smaller, AI-native companies, and that his model-neutral agent platform is built to serve them. He traces Perplexity's evolution from answer engine to Perplexity Computer, citing 5x revenue growth and one solopreneur spending over $1M annually while making $3M. He argues AI products have recursive effects, not network effects, so user depth beats user counts. He explains local and hybrid AI with NVIDIA and Apple, rules out building Perplexity data centers, and describes sovereign deployments for data-wary governments. He ends with his hiring-by-trials method, Larry Page's 'user is never wrong' philosophy, and his bet on long-horizon agents turning everyone into a scientist.

USV’s New $900M Fund: Fred Wilson, Rebecca Kaden & Mike Mignano

Oct 8, 2026 · 1:25:14

Union Square Ventures partners Fred Wilson, Rebecca Kaden and Mike Mignano explain why the firm broke its small-fund discipline to raise $900M, its largest fund cycle ever, as bigger AI outcomes and costlier rounds demand larger checks. Wilson says AI today looks like the internet in 2003: infrastructure is built, but defining applications remain unbuilt. The partners detail 'obliterate, don't automate'—an AI lawyer, accountant or doctor instead of a human one—arguing incumbents can't copy it because it cannibalizes their business. Wilson calls ARR a 'fake metric,' favoring usage retention, and says single-digit-billion exits still return well at USV's fund size. The 'Rebel Alliance' thesis backs open-source AI infrastructure, and Mignano argues chatbots won't replace the user interface.

Stripe’s John Collison: AI Agents Will Rewire the Internet

Oct 5, 2026 · 28:01

Stripe co-founder John Collison tells host Molly O'Shea that AI agents will rewire commerce, calling computer use the "ultimate backwards compatibility layer" for the real world. Collison says Stripe processed $1.9 trillion in 2025, up 34%, and almost no one now integrates its API by hand, so Stripe is rebuilding for "AI ergonomics" rather than developer ergonomics. He argues AI discovery will reshuffle merchants the way Facebook ad targeting did, predicts more breaches over the next five years, and says Stripe deems January 1, 2026 the start of its "singularity epoch." He explains the Bridge, Privy, Metronome and OpenRouter acquisitions—crypto, usage-based billing, model routing—and internal AI wins like legal agents. His 17-year lessons: no shortcuts, stickwithness, users first.

We’re Reaching the Physical Limits of Chips

Sep 30, 2026 · 13:41

Molly O'Shea asks what comes after the GPU with Steven Latré, VP of AI at imec, and Adam Chambers of Strike Capital, who argue that AI's real bottlenecks now sit in memory, power, cooling and data transfer rather than compute. Latré says the world's biggest chipmakers come through imec's unique Belgian clean room years before chips ship, that transistors at roughly one nanometer are at the end of physics of Moore's Law scaling, and that the era of ever-bigger models — from 175 billion to 10 trillion parameters — is ending. Chambers notes only Micron, SK Hynix and Samsung make 95% of memory — prices rose 700% this year — and calls photonics the key technology likely to win, moving from pluggable optics to co-packaged optics near the GPU. Latré's hottest take: in 5-10 years we'll laugh at today's LLMs like dial-up internet.

The $500B Opportunity in Europe’s Defense Buildout

Sep 30, 2026 · 21:51

Molly O'Shea interviews Aistis Šimaitis (Co-Founder & CEO of Onodrim), George Hadjiminas (Chief Strategy Officer at Theon International), and Bruno Wejchert (Partner at Strike Capital) on why Europe's €800B defense buildout depends on manufacturing scale, not just new technology. Aistis argues 'volume wins'—systems must be produced in tens of thousands to millions, forcing prices like a $30,000 radio far lower for autonomous warfare. George warns 'prototypes don't fight wars,' claiming Europe's tech capabilities rival America's despite too many protected national champions. Bruno, citing component lead times of years and primes taking 4–5 years to deliver contracts, predicts a half-trillion-dollar European defense company founded in the last five years could emerge within the next decade.

The $3B Company Trying to Beat Amazon Prime

Sep 29, 2026 · 14:32

Stord founder and CEO Sean Henry argues value from AI and robotics will accrue to real-world operators like his company, not the technology companies themselves. Henry tells host Molly O'Shea Stord is crossing $1 billion in annual revenue this year after 10Xing over four years on a $250M Series F, processing 100 million packages a year to a third of U.S. households and nearly $20 billion in GMV. He explains how Stord's 8 billion annual operational data points accelerate robotics learning, why humanoids are stuck in pilots since humans are an inefficient form factor, and how acquisitions yield five to seven times efficiency uplift. He credits his start as a Thiel Fellow at 19 and argues AI and robotics companies will be commoditized while physical businesses like Stord win.

The Sales Machine Behind $17.3B Deel

Sep 29, 2026 · 12:49

Shuo Wang, co-founder and CRO of payroll platform Deel, tells Molly O'Shea that the company grew from $100M to $1B in ARR in 3 years and has surpassed $1.5B in revenue at a $17.3B valuation. She credits going global from day one — Deel runs its own entities, compliance and payroll teams in 160 countries — and argues founders simply aren't selling enough. The MIT-trained robotics engineer applies systems thinking to sales: understand what clients want, then incentivize a remote sales team across 120 countries, unified by an annual 1,500-person kickoff. She describes complementing CEO co-founder Alex Bouaziz, cites James Dyson and Jeff Bezos as inspirations, touts a Snoop Dogg campaign paying $10,000 a month for ice cream testers, and says AI hasn't yet grabbed Europe like San Francisco.

The Wildest Hot Takes From the All-In Summit 2026

Sep 27, 2026 · 47:20

At the All-In Summit 2026, Brad Gerstner of Altimeter says the AI safety debate is settling into a pragmatic consensus around independent peer review, while Naveen Rao of Unconventional AI claims his chips are thousands of times more efficient and calls software near-worthless in 20 years. Jonathan Neman of Sweetgreen argues AI won't kill you but ultra-processed food will. Toby Rice of EQT forecasts 20 to 40% more natural gas demand from AI power generation. Kent Draper of IREN says compute demand far exceeds supply, Wen Sang of Genspark says don't slow AI down, Geoff Woo of Anti Fund denies free will, Nick Shirley calls California's $200 billion high-speed rail wasteful, Jake Paul wants the Constitution updated, and Michael Brandt of Ketone-IQ calls the human body the next tech platform.

Brad Gerstner: The Great Wealth Transfer to 70 Million American Kids

Sep 20, 2026 · 12:41

Brad Gerstner, founder of Invest America, argues Trump Accounts will reach $4 trillion in 10 years — a wealth transfer to kids who would otherwise have had zero. At the All In Summit, Gerstner demos a live $150 contribution to Derek Harris's account via QR code and Apple Pay. He says 9 million accounts exist today, scaling to 70 million for all kids under 18 within 30 days — its 'IPO' — as Michael Dell's $250 deposits and Gerstner's Indiana dollars land. He compares company contributions to 401(k)s, describes Texas teaching compounding to 750,000 kids, and recounts Trump calling the Speaker to pass the law, citing backing from Booker, Newsom, and Bill Clinton. He closes arguing the summit's AI panels show consensus forming around independent peer review and lab responsibility.

The $100 Heart Scan Brad Gerstner Says Could Save Your Life

Sep 16, 2026 · 23:39

Brad Gerstner and Jason Chang's Center for Heart Attack Prevention aims to make the $100 coronary artery calcium CT scan the 'mammogram for the heart,' scaling to 40M scans a year to save 50,000 lives and $20B in government costs. Gerstner tells Molly O'Shea heart disease kills 800,000 Americans a year, half of heart attack victims have normal cholesterol, and the stent lobby beat the calcium scanner in Washington. Rob Goldberg tells how his brother Dave, Sheryl Sandberg's husband, died at 47 of undiagnosed heart disease despite passing a running EKG five months earlier — the death behind her book Option B. Gerstner recommends a CAC for anyone over 35, an angiogram only for non-zero scores, and a buy one, give one model; he expects Medicare and Medicaid coverage by year's end.

Bending Spoons Founders on Buying Airtable, AOL, Vimeo & Eventbrite

Sep 14, 2026 · 1:17:47

Bending Spoons CEO Luca Ferrari and co-founders Francesco Patarnello and Matteo Danieli join AOL GM Valentina Jerusalmi to tell Molly O'Shea why the company buys businesses like AOL, Airtable, Vimeo, Evernote, and Miro and never sells them. Patarnello recounts the failed 2019 Grindr bid, worth $20B at today's scale, that built financing muscle from a $1–2M loan in 2017 to US term loans in 2025, then explains selecting 5–10 of 1,000 yearly targets on value-unlock, scale, and predictability. Dropping vesting and annual tenders keep churn under 1%, while founders sell for a forever home without lock-ins. Danieli explains stepping down as CPO for a stronger hire—every role, even CEO, is up for grabs—and 'startup mode' revivals. Jerusalmi covers the Yahoo carve-out and A/B testing.

Saronic's 4 Co-Founders on Building a $9.25B Shipbuilder | Part III

Sep 10, 2026 · 59:52

Saronic's co-founders Doug Lambert, Rob Lehman, and Vibhav Altekar join Molly O'Shea to argue autonomous mass production, not exquisite manned ships, decides naval power as China outbuilds the U.S. 230 to 1—1,000+ commercial ships in 2024 to America's 5. COO Doug Lambert details the $3B Port Alpha shipyard, aluminum welding with Path Robotics, Palantir Foundry for manufacturing, and why casting, forging, and wire harnessing must return to the U.S. Rob Lehman says only 1% of the Department of War's ~$1T budget goes to autonomy, wants AI tooling so contracting officers can say yes, and aims to thank two Apache pilots Saronic tech helped. CTO Vibhav Altekar explains hardware-software co-design for 20-G impacts, redundant comms against jamming, the Nvidia partnership, and open-source AI.

Dino Mavrookas: America Needs to Build Ships Again

Sep 8, 2026 · 29:56

Dino Mavrookas, Co-Founder & CEO of Saronic, argues America's shipbuilding gap—China outbuilds the U.S. 230 to 1, having built over 1,000 commercial ships last year against 5—is a national security crisis only autonomy and private capital can fix. He notes the Navy's 290 ships fall short of Congress's 355 minimum and the revised 381-ship need, and explains how Saronic's Corsair, Marauder and $3 billion Port Alpha shipyard—10,000 jobs and $160 billion of impact in Brownsville—answer that. He predicts 5 to 10 new defense primes in a decade and describes a Castellan partnership to launch a hypersonic missile off an autonomous ship before the Navy can from a manned one. He also recounts founding Saronic in 2022 after leaving private equity, his wife naming it after the Battle of Salamis.

Inside Saronic’s $9.25B Autonomous Boat Factory | CEO Dino Mavrookas

Sep 7, 2026 · 33:01

Saronic co-founder and CEO Dino Mavrookas tours Molly O'Shea through the company's 420,000 sqft autonomous boat factory in Austin, Texas, arguing vertical integration of hardware and software took the 2022 startup to a $9.25B valuation. He shows the Corsair line, which can build 2,000 boats per year, and credits its linear flow with exposing bottlenecks. He boards Mirage, a 52-foot vessel with 2,500 nautical miles of range and 3,500 lbs of payload, and points to Marauder, a 180-foot ship. Port Alpha, the Brownsville shipyard on 800 acres, will add 150,000 gross tons — 1.5X U.S. capacity — and 10,000 jobs vs. China's 230-to-1 lead. He traces the $800 Amazon-raft origins, the $392 million Navy contract, and Corsair combat use in the Strait of Hormuz, including an autonomous rescue.

Bridgit Mendler Gives Us the First Tour of Northwood's New HQ + Factory

Aug 31, 2026 · 46:17

Bridgit Mendler, co-founder and CEO of Northwood Space, gives Molly O'Shea a tour of the new 185,000 sqft Torrance factory and argues the neglected ground segment is the space economy's biggest bottleneck. Northwood has raised over $136M since 2022, including a $100M Series B led by Washington Harbour and Andreessen Horowitz, and holds a $49.8M Space Force contract for the Satellite Control Network. The factory will 5x capacity, add 400 jobs, and support hundreds of antennas a year; she explains why ground tech hasn't changed since the 1990s and how Northwood brings Portal/Prism production, machining, PCB assembly, and anechoic testing in-house. She also covers site licensing, colocation, supply-chain choices, national-security concerns, and mission ops moving into the former movie theater.

Inside AppLovin’s $100B Ad Engine

Aug 14, 2026 · 1:26:38

AppLovin CEO Adam Foroughi and CTO Giovanni Ge explain how AppLovin rebuilt its ad engine with Axon 2 after a 92% post-IPO stock drop, driving recovery from $5.5B to a $100B+ company. Ge details replacing tree-based models with neural embeddings so predictions became more accurate and GPU-cheaper, and says Axon 2's success came from deciding what not to build. Foroughi describes keeping engineering at ~100 people, using AI to elevate rather than replace engineers, expanding from mobile gaming into e-commerce via a napkin-designed data pipeline, and moving ads into connected TV and open web. They discuss why AI-generated ads need human guardrails, why taste matters more than building speed, and the path to a trillion-dollar valuation requiring $30B+ annual cash flow, plus buybacks during the downturn.